PHYLIP - Phylogeny Inference Package (version 3.6) PHYLIP (the PHYLogeny Inference Package) is a package of programs for inferring phylogenies (evolutionary trees). Methods that are available in the package include parsimony, distance matrix, and likelihood methods, including bootstrapping and consensus trees. Data types that can be handled include molecular sequences, gene frequencies, restriction sites, distance matrices, and 0/1 discrete characters. The programs are controlled through a menu, which asks the users which options they want to set, and allows them to start the computation. The data are read into the program from a text file, which the user can prepare using any word processor or text editor (but it is important that this text file not be in the special format of that word processor -- it should instead be in "flat ASCII" or "Text Only" format). Some sequence analysis programs such as alignment programs can write data files in the PHYLIP format. Most of the programs look for the data in a file called "infile" -- if they do not find this file they then ask the user to type in the file name of the data file. Output is written onto special files with names like "outfile" and "treefile". Trees written onto "treefile" are in the Newick format, an informal standard agreed to in 1986 by authors of a number of major phylogeny packages. PHYLIP is the most widely-distributed phylogeny package, and competes with PAUP to be the one responsible for the largest number of published trees. PHYLIP has been in distribution since 1980, and has over 6,000 registered users. Joe Felsenstein joe@genetics.washington.edu Department of Genetics University of Washington Box 357360 Seattle, Washington 98195-7360, U.S.A. WWW: http://evolution.genetics.washington.edu/phylip.html