Macholib can be used to analyze and edit Mach-O headers, 
the executable format used by Mac OS X.

It is typically used as a dependency analysis tool, and 
also to rewrite dylib references in Mach-O headers to be 
@executable_path relative.

Though this tool targets a platform specific file format, 
it is pure python code that is platform and endian independent.

WWW: https://pypi.org/project/macholib/