Macholib can be used to analyze and edit Mach-O headers, the executable format used by Mac OS X. It is typically used as a dependency analysis tool, and also to rewrite dylib references in Mach-O headers to be @executable_path relative. Though this tool targets a platform specific file format, it is pure python code that is platform and endian independent. WWW: https://pypi.org/project/macholib/